Some novel 2-aminopyrimidine derivatives 5a-j were synthesized by claisen-schmidt condensation of 3-acetyl-2,5-\r\ndimethylthiophene and different substituted aromatic aldehydes to give respective chalcones and further cyclised with\r\nguanidine in ethanol in reflux conditions to give respective 2-aminpyrimidines 5a-j. All the synthesized compounds were\r\ncharacterized by physical and spectral data. The compounds were screened for anti-microbial activities. Compounds 5g and 5e\r\nwere found to possess significant anti bacterial activity against both gram positive and gram negative bacteria at the tested\r\nconcentrations when compared with that of standard drug ampicillin. In anti-fungal study, compounds 5h, 5f and 5g have\r\nexhibited significant anti fungal activity when compared with standard drug fluconazole. These compounds can be further\r\nexploited to get the potent lead compound.
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